Last edited by Goose (6/28/2017 3:29 pm)

Today, polio is a fading memory.
It was once a terror to parents all over the world.





Jonas Edward Salk



Jonas Salk was an American medical researcher and virologist. He discovered and developed one of the first successful polio vaccines. Born in New York City, he attended New York University School of Medicine, later choosing to do medical research instead of becoming a practicing physician. In 1939, after earning his medical degree, Salk began an internship as a scientist physician at Mount Sinai Hospital. Two years later he was granted a fellowship at the University of Michigan, where he would study flu viruses with his mentor Thomas Francis, Jr..

Until 1955, when the Salk vaccine was introduced, polio was considered one of the most frightening public health problems in the world. In the postwar United States, annual epidemics were increasingly devastating. The 1952 U.S. epidemic was the worst outbreak in the nation's history. Of nearly 58,000 cases reported that year, 3,145 people died and 21,269 were left with mild to disabling paralysis, with most of its victims being children. The "public reaction was to a plague", said historian William L. O'Neill. "Citizens of urban areas were to be terrified every summer when this frightful visitor returned." According to a 2009 PBS documentary, "Apart from the atomic bomb, America's greatest fear was polio." As a result, scientists were in a frantic race to find a way to prevent or cure the disease. In 1938, U.S. President Franklin D. Roosevelt, the world's most recognized victim of the disease, had founded the National Foundation for Infantile Paralysis (known as March of Dimes Foundation since 2007), an organization that would fund the development of a vaccine.

In 1947, Salk accepted an appointment to the University of Pittsburgh School of Medicine. In 1948, he undertook a project funded by the National Foundation for Infantile Paralysis to determine the number of different types of polio virus. Salk saw an opportunity to extend this project towards developing a vaccine against polio, and, together with the skilled research team he assembled, devoted himself to this work for the next seven years. The field trial set up to test the Salk vaccine was, according to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers." Over 1,800,000 school children took part in the trial. When news of the vaccine's success was made public on April 12, 1955, Salk was hailed as a "miracle worker" and the day almost became a national holiday.

https://en.wikipedia.org/wiki/Jonas_Salk

Last edited by Goose (6/29/2017 5:13 am)

Frances Oldham Kelsey

As a reviewer for the U.S. Food and Drug Administration (FDA), Kelsey refused to authorize the drug thalidomide for market because she had concerns about the drug's safety. Her concerns proved to be justified when it was shown that thalidomide caused serious birth defects. Kelsey's career intersected with the passage of laws strengthening FDA oversight of pharmaceuticals. Kelsey was the second woman to be awarded the President's Award for Distinguished Federal Civilian Service by President John F. Kennedy.


Thalidomide was a drug first marketed in 1957 in West Germany under the trade-name Contergan. The German drug company Chemie Grünenthal developed and sold the drug. Primarily prescribed as a sedative  thalidomide also claimed to cure "anxiety, insomnia, gastritis, and tension". Afterwards, it was used against nausea and to alleviate morning sickness in pregnant women. Thalidomide became an over-the-counter drug in West Germany on October 1, 1957. Shortly after the drug was sold in West Germany, between 5,000 and 7,000 infants were born with phocomelia (malformation of the limbs). Only 40% of these children survived.




In the U.S., representatives from Chemie Grünenthal approached Smith, Kline & French (SKF), now GlaxoSmithKline (GSK) with a request to market and distribute the drug in North America.

The U.S. FDA refused to approve thalidomide for marketing and distribution. However, the drug was distributed in large quantities for testing purposes, after the American distributor and manufacturer Richardson-Merrell had applied for its approval in September 1960.

The official in charge of the FDA review, Frances Oldham Kelsey, did not rely on information from the company, which did not include any test results. Richardson-Merrell was called on to perform tests and report the results. The company demanded approval six times, and was refused each time.

For correctly denying the application despite the pressure from Richardson-Merrell, Kelsey eventually received the President's Award for Distinguished Federal Civilian Service at a 1962 ceremony with President John F. Kennedy.





In September 2010, the FDA honored Kelsey with the first Kelsey award. The award, given annually to an FDA staff member, came 50 years after Kelsey, then a new medical officer at the agency, first reviewed the application from the William S. Merrell Company of Cincinnati. Cardiologist Helen B. Taussig learned of the damaging effects of the drug thalidomide on newborns and in 1967, testified before Congress on this matter after a trip to Germany where she worked with infants with phocomelia (severe limb deformities).

As a result of her efforts, thalidomide was banned in the United States and Europe.


 

The Four Chaplains

The Four Chaplains, also sometimes referred to as the "Immortal Chaplains" or the "Dorchester Chaplains", were four United States Army chaplains who gave their lives to save other civilian and military personnel as the troop ship SS Dorchester sank on February 3, 1943, during World War II. They helped other soldiers board lifeboats and gave up their own life jackets when the supply ran out. The chaplains joined arms, said prayers, and sang hymns as they went down with the ship.


The relatively new chaplains all held the rank of first lieutenant. They included Methodist minister the Reverend George L. Fox, Reform Rabbi Alexander D. Goode (Ph.D.), Roman Catholic priest Father John P. Washington, and Reformed Church in America minister the Reverend Clark V. Poling. Their backgrounds, personalities, and denominations were different, although Goode, Poling and Washington had all served as leaders in the Boy Scouts of America. They met at the Army Chaplains School at Harvard University, where they prepared for assignments in the European theater, sailing on board Dorchester to report to their new assignments in Guatemala.

Dorchester left New York on January 23, 1943, en route to Greenland, carrying the four chaplains and approximately 900 others, as part of a convoy of three ships (SG-19 convoy). Most of the military personnel were not told the ship's ultimate destination. The convoy was escorted by Coast Guard Cutters Tampa, Escanaba, and Comanche.

The ship's captain, Hans J. Danielsen, had been alerted that Coast Guard sonar had detected a submarine. Because German U-boats were monitoring sea lanes and had attacked and sunk ships earlier during the war, Captain Danielsen had the ship's crew on a state of high alert even before he received that information, ordering the men to sleep in their clothing and keep their life jackets on. "Many soldiers sleeping deep in the ship's hold disregarded the order because of the engine's heat. Others ignored it because the life jackets were uncomfortable."

During the early morning hours of February 3, 1943, at 12:55 a.m., the vessel was torpedoed by the German submarine U-223 off Newfoundland in the North Atlantic.









The torpedo knocked out the Dorchester's electrical system, leaving the ship dark. Panic set in among the men on board, many of them trapped below decks. The chaplains sought to calm the men and organize an orderly evacuation of the ship, and helped guide wounded men to safety. As life jackets were passed out to the men, the supply ran out before each man had one. The chaplains removed their own life jackets and gave them to others. They helped as many men as they could into lifeboats, and then linked arms and, saying prayers and singing hymns, went down with the ship.

As I swam away from the ship, I looked back. The flares had lighted everything. The bow came up high and she slid under. The last thing I saw, the Four Chaplains were up there praying for the safety of the men. They had done everything they could. I did not see them again. They themselves did not have a chance without their life jackets.

— Grady Clark, survivor

Last edited by Goose (7/02/2017 1:34 pm)

Goose wrote:

The Four Chaplains

The Four Chaplains, also sometimes referred to as the "Immortal Chaplains" or the "Dorchester Chaplains", were four United States Army chaplains who gave their lives to save other civilian and military personnel as the troop ship SS Dorchester sank on February 3, 1943, during World War II. They helped other soldiers board lifeboats and gave up their own life jackets when the supply ran out. The chaplains joined arms, said prayers, and sang hymns as they went down with the ship.


The relatively new chaplains all held the rank of first lieutenant. They included Methodist minister the Reverend George L. Fox, Reform Rabbi Alexander D. Goode (Ph.D.), Roman Catholic priest Father John P. Washington, and Reformed Church in America minister the Reverend Clark V. Poling. Their backgrounds, personalities, and denominations were different, although Goode, Poling and Washington had all served as leaders in the Boy Scouts of America. They met at the Army Chaplains School at Harvard University, where they prepared for assignments in the European theater, sailing on board Dorchester to report to their new assignments in Guatemala.

Dorchester left New York on January 23, 1943, en route to Greenland, carrying the four chaplains and approximately 900 others, as part of a convoy of three ships (SG-19 convoy). Most of the military personnel were not told the ship's ultimate destination. The convoy was escorted by Coast Guard Cutters Tampa, Escanaba, and Comanche.

The ship's captain, Hans J. Danielsen, had been alerted that Coast Guard sonar had detected a submarine. Because German U-boats were monitoring sea lanes and had attacked and sunk ships earlier during the war, Captain Danielsen had the ship's crew on a state of high alert even before he received that information, ordering the men to sleep in their clothing and keep their life jackets on. "Many soldiers sleeping deep in the ship's hold disregarded the order because of the engine's heat. Others ignored it because the life jackets were uncomfortable."

During the early morning hours of February 3, 1943, at 12:55 a.m., the vessel was torpedoed by the German submarine U-223 off Newfoundland in the North Atlantic.









The torpedo knocked out the Dorchester's electrical system, leaving the ship dark. Panic set in among the men on board, many of them trapped below decks. The chaplains sought to calm the men and organize an orderly evacuation of the ship, and helped guide wounded men to safety. As life jackets were passed out to the men, the supply ran out before each man had one. The chaplains removed their own life jackets and gave them to others. They helped as many men as they could into lifeboats, and then linked arms and, saying prayers and singing hymns, went down with the ship.

As I swam away from the ship, I looked back. The flares had lighted everything. The bow came up high and she slid under. The last thing I saw, the Four Chaplains were up there praying for the safety of the men. They had done everything they could. I did not see them again. They themselves did not have a chance without their life jackets.

— Grady Clark, survivor

I went to Goode's namesake elementary school in York